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Members of the caspase family play key roles in inflammation and mammalian apoptosis. Z-LEHD-FMK is an irreversible and cell permeable inhibitor of caspase-9. The peptide is O-methylated in the P1 position on aspartic acid providing enhanced stability and increased cell permeability. Z-LEHD-FMK can be used to inhibit primarily caspase-9 activity and to study events downsteam of caspase-9 activation. Z-LEHD-FMK has been reported to have a molecular weight of 804 Daltons.
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