Any use of products other than the permitted use without the express written authorization of Becton, Dickinson and Company is strictly prohibited.
The loss of plasma asymmetry is a key feature of apoptosis. In normal cells, membrane phospholipids are distributed asymmetrically between the inner and outer leaflets of the plasma membrane. For example, phosphatidylserine (PS), an aminophospholipid, is normally present in the inner leaflet of the plasma membrane. Early in apoptosis, before the loss of membrane integrity, PS translocates from the inner to the outer leaflet of the plasma membrane, exposing it to the external cellular environment at the surface of the plasma membrane. Annexin V is a 35-36 kDa, calcium-dependent, phospholipid-binding protein with a high affinity for PS and is used to indirectly monitor PS translocation. The Annexin V assay is perhaps the most widely used assay today, facilitated by the observation that PS translocation appears to be a universal apoptotic phenomenon. It has been detected in mammalian, insect, and plant cells under the action of most, if not all, triggers of apoptosis.
温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知,且每位咨询者购买情况、提问时间等不同,为此以下回复仅对提问者3天内有效,其他网友仅供参考!若由此给您带来不便请多多谅解,谢谢!
服务热线
0771-3293894