Pifithrin-β是有效地p53抑制剂,IC50值为23 μM。
Description | Pifithrin-β is a potent p53 inhibitor with an IC50 of 23 μM. | ||||||||||||||||
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IC50 & Target | IC50: 23 μM (p53)[1] | ||||||||||||||||
In Vitro | Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : 26 mg/mL (74.44 mM; Need ultrasonic and warming) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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