SJSA-1 cells cells are treated with AM-8735 for 16 hours in the presence of 10% human serum. Cell proliferation is measured by the Click-iT EdU assay^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rats^[1]

SJSA-1 cells (5 × 10⁶) are implanted subcutaneously into female athymic nude mice. AM-8735 is administered by oral gavage (as a solution in 15% HPβCD, 1% Pluronic F68, pH 8) 5, 25, 50, and 100 mg/kg q.d. for a period of 2 weeks, and tumor volume is quantified^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Gonzalez AZ, et al. Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem. 2014 Mar 27;57(6):2472-88.

568.51

C₂₇H₃₁Cl₂NO₆S

1429386-01-5

O=C(N1[C@H](CS(=O)(C(C)(C)C)=O)C2CC2)[C@@H](CC(O)=O)O[C@H](C3=CC=CC(Cl)=C3)[C@H]1C4=CC=C(Cl)C=C4

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US; may vary elsewhere