RG7388 是一种有效,选择性的 MDM2 拮抗剂,能够抑制 p53-MDM2 的结合,IC50 值为 6 nM。
Description | RG7388 is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM. | ||||||||||||||||
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IC50 & Target | IC50: 6 nM (p53-MDM2)[1] | ||||||||||||||||
In Vitro | |||||||||||||||||
In Vivo | |||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 45 mg/mL (73.00 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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