MX69 是一种 MDM2/XIAP 抑制剂,常用于抗癌研究。
Description | MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment. | ||||||||||||||||
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In Vitro | MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro[1]. | ||||||||||||||||
In Vivo | MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo[1]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 30 mg/mL (63.22 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References |
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