Piperazine Erastin 纯度:99.75% 50mg

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Piperazine Erastin 纯度:99.75% 50mg

市场价：: 11000.00

促销价：: ¥11000.00

货号：HY-100887

品牌：MCE

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北京朝阳

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商品介绍
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Piperazine erastin是erastin的类似物，其诱导铁离子依赖形式的非凋亡性细胞死亡，称为铁死亡。

Description

Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis.

In Vitro

Erastin is a ferroptosis activator. It triggers a unique iron-dependent form of non-apoptotic cell death that is termed as ferroptosis. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable. Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds^[1].

In Vivo

In the xenograft mouse model, a significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group. Ptgs2 is upregulated in mouse liver with 10 or 60 mg/kg piperazine erastin administration^[1].

Solvent & Solubility

In Vitro:

DMSO : ≥ 83.3 mg/mL (129.11 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5499 mL	7.7497 mL	15.4993 mL
5 mM	0.3100 mL	1.5499 mL	3.0999 mL
10 mM	0.1550 mL	0.7750 mL	1.5499 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331.

Animal Administration ^[1]	Mice: Athymic nude mice are injected with four million HT-1080 cells s.c. The next day, 400 μL of vehicle (0.625% DMSO/99.375% HBSS [pH 2]) or 40 mg/kg piperazine erastin is delivered to the s.c. site where cancer cells are injected. Two days later, the s.c. injection is repeated. Three days later, 300 μL of vehicle or 30 mg/kg piperazine erastin is administered to the mice through tail vein. Tail vein injection is repeated three more times, once every other day before the final tumor size is measured in both groups^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Yang WS, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1-2):317-331.

Animal Administration
^[1]

Mice: Athymic nude mice are injected with four million HT-1080 cells s.c. The next day, 400 μL of vehicle (0.625% DMSO/99.375% HBSS [pH 2]) or 40 mg/kg piperazine erastin is delivered to the s.c. site where cancer cells are injected. Two days later, the s.c. injection is repeated. Three days later, 300 μL of vehicle or 30 mg/kg piperazine erastin is administered to the mice through tail vein. Tail vein injection is repeated three more times, once every other day before the final tumor size is measured in both groups^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References