Ferrostatin-1 是 ferroptosis 的强效抑制剂,其 EC50 值为 60 nM。
Description | Ferrostatin-1 is a potent inhibitor of ferroptosis with an EC50 of 60 nM. | ||||||||||||||||
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IC50 & Target | EC50: 60 nM (Ferroptosis)[1] | ||||||||||||||||
In Vitro | Ferrostatin-1 is the most potent inhibitor of erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1 does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS[1]. Cells pretreated with 0.4 μM Ferrostatin-1 displays significantly reduce intracellular reactive oxygen species (ROS) and nitrogen species (RNS) below basal levels. Additionally, increased intracellular ROS levels are also significantly lowered below basal levels by a 0.4 µM Ferrostatin-1 pretreatment. Ferrostatin-1 treatment for 24 h does not change the expression level of i-NOS in SHSY-5Y cell when compare with vehicle (0.02 % DMSO) treated cells[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 150 mg/mL (571.76 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References |
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