TC-DAPK 6 是一种有效的ATP竞争性的选择性 DAPK 抑制剂,作用于 DAPK1 和 DAPK3,IC50 分别为 69 和 225 nM。
Description | TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP). | ||||||||||||||||
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IC50 & Target | IC50: 69 nM (DAPK1), 225 nM (DAPK3)[1] | ||||||||||||||||
In Vitro | TC-DAPK 6 is found to be the most potent Death-associated protein kinase (DAPK) inhibitor with enzyme selectivity. When assayed with 10 μM ATP, the IC50 values for DAPK1 and DAPK3 are 69 and 225 nM, respectively. TC-DAPK 6 also inhibits p70S6K (1 μM < IC50< 10 μM)[1]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : 18.67 mg/mL (67.57 mM; Need ultrasonic and warming) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References |
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