EP1013 是一种广谱的 caspase 选择性抑制剂,可用于 1 型糖尿病研究。
Description | EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes. | ||||||||||||||||
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IC50 & Target[1] |
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In Vivo | EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal rate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 60 mg/mL (156.91 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References |
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