Sabutoclax 500mg

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Qiagen 凯杰 Biosharp Omega

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首页酶、辅酶及抑制剂MCE>

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商品介绍
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Sabutoclax 是有效的和有选择性的 Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) 抑制剂， IC₅₀ 值分别为 0.32 μM， 0.31 μM， 0.20 μM， 0.62 μM。

Description

Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC₅₀s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

IC₅₀ & Target^[1]

Bcl-xL

0.31 μM (IC₅₀)

BCL2

0.32 μM (IC₅₀)

Mcl-1

0.2 μM (IC₅₀)

Bfl-1

0.62 μM (IC₅₀)

Solvent & Solubility

In Vitro:

10 mM in DMSO

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4270 mL	7.1349 mL	14.2698 mL
5 mM	0.2854 mL	1.4270 mL	2.8540 mL
10 mM	0.1427 mL	0.7135 mL	1.4270 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Wei J , et al. BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. J Med Chem. 2010 May 27; 53(10):4166-76.

Molecular Weight	700.78
Formula	C₄₂H₄₀N₂O₈
CAS No.	1228108-65-3
SMILES	O=C(C1=C(O)C(O)=CC2=C(O)C(C3=C(C)C=C4C(C(NCC(C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NCC(C6=CC=CC=C6)C
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere