Mcl1-IN-3 250mg

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Qiagen 凯杰 Biosharp Omega

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首页酶、辅酶及抑制剂MCE>

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商品介绍
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Mcl1-IN-3是 Mcl1 的抑制剂, 来自专利专利WO2015153959A2，化合物实例57； IC₅₀ 和 K_i 值分别为0.67 和 0.13 μM。

Description

Mcl1-IN-3 is an inhibitor of Mcl1 extracted from patent WO2015153959A2, compound example 57; has an IC₅₀ and K_i of 0.67 and 0.13 μM, respectively.

IC₅₀ & Target

IC50: 0.67 μM (Mcl1)^[1]

Ki: 0.13 μM (Mcl1)

^[1]

Solvent & Solubility

In Vitro:

10 mM in DMSO

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0495 mL	10.2474 mL	20.4947 mL
5 mM	0.4099 mL	2.0495 mL	4.0989 mL
10 mM	0.2049 mL	1.0247 mL	2.0495 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Nikolovska-Coleska Z, et al. Pyrazolopyridines as inhibitors of Mcl-1 and and their preparation. WO2015153959A2

Molecular Weight	487.93
Formula	C₂₇H₂₂ClN₃O₄
CAS No.	1814891-79-6
SMILES	CC1=NN(CC2=CC=C(OC3=CC(C)=C(Cl)C(C)=C3)C=C2)C4=C1C(C(O)=O)=CC(C5=CC=CO5)=N4
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere