WEHI-539 是一种选择性的 Bcl-XL 抑制剂,IC50 为 1.1 nM。
Description | WEHI-539 is a selective inhibitor of Bcl-XL with IC50 of 1.1 nM. | ||||||||||||||||
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IC50 & Target[1] |
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In Vitro | WEHI-539 is a selective inhibitor of Bcl-XL. WEHI-539 augments Carboplatin induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: 10 mM in DMSO Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References |
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