Bax inhibitor peptide V5 是一种 Bax 诱导凋亡的抑制剂,主要用于癌症研究。
Description | Bax inhibitor peptide V5 is a Bax-mediated apoptosis inhibitor, used for cancer treatment. | ||||||||||||||||
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IC50 & Target[1] |
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In Vitro | Bax inhibitor peptide V5 (0-50 μM) reduces cell death in STF-cMyc cells but not in SW620 or NCI-H23 cells. BIPV5 does not result in any significant effect on cell cycle arrest at the G2/M phase[1]. V5 treatment upregulates expression of anti-apoptotic proteins Bcl-2 and XIAP by more than 3- and 11-fold and downregulates expression of apoptosis-inducing proteins Bax, Bad, and nuclear factor-κB-p65 by 10, 30, and nearly 50%, respectively[2]. | ||||||||||||||||
In Vivo | V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation in mice model[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 30 mg/mL (51.13 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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