A-1155463是高效选择性的BCL-XL抑制剂,在Molt-4细胞中的EC50值为70 nM。
Description | A-1155463 is a highly potent and selective BCL-XL inhibitor with a EC50 value of 70 nM in Molt-4 cell. | ||||||||||||||||
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IC50 & Target[2] |
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In Vitro | A-1155463 shows picomolar binding affinity to BCL-XL (Ki<0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki= 80 nM) and related proteins BCL-W (Ki= 19 nM) and MCL-1 (Ki> 440 nM) [2]. A-1155463 demonstrates strong growth inhibition of over half of the colorectal cell lines as defined by EC50 values ≤0.5 μM in the presence of 10 % FBS[3]. | ||||||||||||||||
In Vivo | A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : 50 mg/mL (74.65 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. In Vivo:
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References | |
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