Cholesterol myristate 是中药中天然类固醇。
Description | Cholesterol myristate is a natural steroid present in traditional Chinese medicine. | ||||||||||||||||
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IC50 & Target |
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In Vitro | Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1]. | ||||||||||||||||
Solvent & Solubility | In Vitro: Ethanol : 2 mg/mL (3.35 mM; Need ultrasonic) DMSO : < 1 mg/mL (insoluble or slightly soluble) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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