Kinetin riboside是细胞分裂素类似物,可诱导癌症细胞死亡。抑制HCT-15细胞增殖的IC50值为2.5 μM。
Description | Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM. | ||||||||||||||||
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IC50 & Target | IC50: 2.5 μM (HCT-15 cells)[1] | ||||||||||||||||
In Vitro | Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC50=2.5 μM)[1]. Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure[2]. | ||||||||||||||||
In Vivo | Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 29 mg/mL (83.49 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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