Ubiquitin Isopeptidase Inhibitor I, G5 纯度:>98.0% 200mg

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Ubiquitin Isopeptidase Inhibitor I, G5 纯度:>98.0% 200mg

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商品介绍
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Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC₅₀值分别为1.76和1.6 μM。

Description

Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC₅₀ values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

IC₅₀ & Target

IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)^[1]

In Vitro

G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC₅₀s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively^[1].

Solvent & Solubility

In Vitro:

DMSO : ≥ 31 mg/mL (74.81 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4132 mL	12.0659 mL	24.1319 mL
5 mM	0.4826 mL	2.4132 mL	4.8264 mL
10 mM	0.2413 mL	1.2066 mL	2.4132 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Aleo E, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44.

Cell Assay ^[1]	Different drug concentrations are used to determine the dose-response profile and to calculate the IC₅₀ value. Cells are incubated with the required concentrations of the 57 compounds. After 24 or 48 hours of incubation, cell death is evaluated bytr ypan blue staining^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Aleo E, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44.