Polydatin提取自从传统中药虎杖根,在多个实验模型中具有抗炎作用。
Description | Polydatin (Piceid), extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. | ||||||||||||||||
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IC50 & Target | NF-κB, Autophagy | ||||||||||||||||
In Vitro | Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells[1]. | ||||||||||||||||
In Vivo | Polydatin could significantly increase the activity of SOD and the heart rate, attenuate myocardial pathological damage, decrease MDA content, slightly increase arterial pressure and GSH-Px activity, reduce intervals of QRS, QT and ST, and lower FFA content[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 29 mg/mL (74.29 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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