Campathecin 是有效的 DNA拓扑异构酶 I 抑制剂,IC50 值为 679 nM。
Description | Campathecin is a potent DNA enzyme topoisomerase I inhibitor, with an IC50 of 679 nM. | ||||||||||||||||
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IC50 & Target |
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In Vitro | [3H]BrCPT labeling of topoisomerase I is enhanced greatly by the presence of DNA; very little labeling of isolated topoisomerase I or isolated DNA occurrs. Even in the presence of DNA, [3H]BrCPT labeling of topoisomerase I is inhibited by camptothecin, suggesting that both CPT and BrCPT bind to the same site on the DNA-topoisomerase I binary complex[1]. With increasing concentrations of camptothecin, closed circular pRR322 DNA (form I) is converted to nicked circular DNA (form 11). This apparent nicking activitv of camptothecin required DNA topoisomerase I[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : 20.66 mg/mL (59.31 mM; Need warming) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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