ALS-8176是呼吸道合胞病毒(RSV)聚合酶的抑制剂。
Description | ALS-8176 an inhibitor of the respiratory syncytial virus (RSV) polymerase. | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
In Vitro | ALS-008176 is an orally bioavailable prodrug of the novel RSV replication inhibitor ALS-008112, a cytidine nucleoside analogue[1]. | ||||||||||||||||
In Vivo | ALS-8176 demonstrates excellent anti-RSV efficacy and safety in a phase 2 clinical RSV challenge study. It exhibits good oral bioavailability and a high level of 2c-TP in vivo. ALS-8176 has excellent stability profiles in formulations (>24 h storage stability in 0.5% methylcellulose aqueous formulation at rt) and simulats gastric and intestinal fluids (half-life >2 h). Its solubility is adequate to support oral administration in solutions with relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following oral administration of ALS-8176 to monkeys[2]. In an adult human challenge study, ALS-8176 has shown efficacy against RSV infection[1]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 50 mg/mL (115.24 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. In Vivo:
| ||||||||||||||||
References | |
温馨提示:因厂家更改产品包装、产地或者更换随机附件等没有任何提前通知,且每位咨询者购买情况、提问时间等不同,为此以下回复仅对提问者3天内有效,其他网友仅供参考!若由此给您带来不便请多多谅解,谢谢!
服务热线
0771-3293894