ALS-8112是高效选择性的呼吸道合胞病毒(RSV)聚合酶的抑制剂。5'-三磷酸ALS-8112抑制RSV聚合酶的IC50值为0.02 μM。
Description | ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM. | ||||||||||||||||
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IC50 & Target | IC50: 0.02 μM (RSV)[1] | ||||||||||||||||
In Vitro | The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis[2]. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination[3]. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM[4]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 47 mg/mL (160.04 mM) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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