Melarsonyl 5mg

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Qiagen 凯杰 Biosharp Omega

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首页酶、辅酶及抑制剂MCE>

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商品介绍
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Melarsonyl (Melarsonic acid) 是一种驱虫剂，可有效抑制寄生虫 (parasite)。

Description

Melarsonyl (Melarsonic acid) is an anthelmintic agent which can inhibit parasite potently.

IC₅₀ & Target

Parasite^[1]

In Vivo

For acute infections produced by T. brucei brucei GVR, Potassium Melarsonyl exhibits trypanocidal activities. Potassium Melarsonyl (Trimelarsan) cures less than 50% mice at a dose of 25 μmol/kg for 4 consecutive days. At 60 μmol/kg, it cures all the mice in a chronic-infection model^[1].

Solvent & Solubility

In Vitro:

10 mM in DMSO

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1914 mL	10.9570 mL	21.9140 mL
5 mM	0.4383 mL	2.1914 mL	4.3828 mL
10 mM	0.2191 mL	1.0957 mL	2.1914 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Loiseau PM, et al. Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution. Antimicrob Agents Chemother. 2000 Nov;44(11):2954-61.

Animal Administration ^[1]	Mice^[1] Mice are infected i.p. with 10⁴ bloodstream trypomastigotes taken from an infected mouse and suspended in 0.1 mL of phosphate-buffered saline, pH 7.2. The infection is allowed to develop for 24 h before treatment is begun. Ten infected mice are used as controls and received only excipient, 1% carboxymethylcellulose by the i.p. route in a 0.1 ml volume. The other mice receive a single dose of the diluted or suspended Potassium Melarsonyl (20, 40, 60 μmol/kg) in the same manner. Six mice are used per dose. The trypanocidal activity is evaluated by the mean survival time of treated mice for each dose^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Loiseau PM, et al. Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution. Antimicrob Agents Chemother. 2000 Nov;44(11):2954-61.

Animal Administration
^[1]

Mice^[1]

Mice are infected i.p. with 10⁴ bloodstream trypomastigotes taken from an infected mouse and suspended in 0.1 mL of phosphate-buffered saline, pH 7.2. The infection is allowed to develop for 24 h before treatment is begun. Ten infected mice are used as controls and received only excipient, 1% carboxymethylcellulose by the i.p. route in a 0.1 ml volume. The other mice receive a single dose of the diluted or suspended Potassium Melarsonyl (20, 40, 60 μmol/kg) in the same manner. Six mice are used per dose. The trypanocidal activity is evaluated by the mean survival time of treated mice for each dose^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Loiseau PM, et al. Contribution of dithiol ligands to in vitro and in vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution. Antimicrob Agents Chemother. 2000 Nov;44(11):2954-61.

Molecular Weight	456.33
Formula	C₁₃H₁₃AsN₆O₄S₂
CAS No.	37526-80-0
SMILES	O=C(C1S[As](C2=CC=C(NC3=NC(N)=NC(N)=N3)C=C2)SC1C(O)=O)O
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere