Sulfasymazine 10mg

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商品介绍
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Sulfasymazine 是一种磺酰胺类药物，表现出抗菌特性。

Description

Sulfasymazine is a sulfonamide drug and displays antibacterial properties.

IC₅₀ & Target

Bacterial^[1]

In Vivo

Sulfasymazine is a sulfonamide drug and displays antibacterial properties. On a dosage basis, Sulfasymazine is from 2 to 10 times more potent than sulfisoxazole; on a blood level basis, Sulfasymazine potency ranges from 0.3 to 1. In acute toxicity studies in mice, the sodium salt of Sulfasymazine is tolerated at 2000 mg/kg orally, and at 1000 mg/kg intraperitoneally^[1].

Solvent & Solubility

In Vitro:

10 mM in DMSO

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2534 mL	16.2670 mL	32.5341 mL
5 mM	0.6507 mL	3.2534 mL	6.5068 mL
10 mM	0.3253 mL	1.6267 mL	3.2534 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1]. Redin GS, et al. An evaluation of sulfasymazine in infections in mice. Chemotherapy. 1966;11(6):309-14.

Animal Administration ^[1]	Carworth Farms CF-1 mice, 4 to 6 weeks of age, weighing 19 to 22 g are used in this study. The mice are infected by intraperitoneal injection of the several bacteria strains. Sulfasymazine is administered either in the diet or in a single dose by gavage. With the drug-diet method, each group of 10 mice is permitted to feed at will from 1 day before infection to 6 days after infection from a common hopper containing Sulfasymazine uniformly mixed with ground Wayne Mouse Blox. The mice are kept under conditions of alternating 3 h periods of light and dark, in order to encourage eating at more or less regular intervals throughout each 24-h period. Drug intakes, as mg per kg of body weight per day, are determined by calculations based on the initial average weight of the mice, the total diet consumed during the treatment period, and the concentration of drug in the diet^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Redin GS, et al. An evaluation of sulfasymazine in infections in mice. Chemotherapy. 1966;11(6):309-14.

Animal Administration
^[1]

Carworth Farms CF-1 mice, 4 to 6 weeks of age, weighing 19 to 22 g are used in this study. The mice are infected by intraperitoneal injection of the several bacteria strains. Sulfasymazine is administered either in the diet or in a single dose by gavage. With the drug-diet method, each group of 10 mice is permitted to feed at will from 1 day before infection to 6 days after infection from a common hopper containing Sulfasymazine uniformly mixed with ground Wayne Mouse Blox. The mice are kept under conditions of alternating 3 h periods of light and dark, in order to encourage eating at more or less regular intervals throughout each 24-h period. Drug intakes, as mg per kg of body weight per day, are determined by calculations based on the initial average weight of the mice, the total diet consumed during the treatment period, and the concentration of drug in the diet^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Redin GS, et al. An evaluation of sulfasymazine in infections in mice. Chemotherapy. 1966;11(6):309-14.

Molecular Weight	307.37
Formula	C₁₃H₁₇N₅O₂S
CAS No.	1984-94-7
SMILES	O=S(C1=CC=C(N)C=C1)(NC2=NC(CC)=NC(CC)=N2)=O
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping	Room temperature in continental US; may vary elsewhere