Ozenoxacin 是一种非氟喹诺酮抗菌剂,能够抵抗大多数从在皮肤和软组织感染中分离的微生物。
Description | Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections. | ||||||||||||||||
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IC50 & Target | Bacterial[1] | ||||||||||||||||
In Vitro | Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positive microorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains of MRSA, MSSA, MSSE, and MRSE with 2, 3, or 4 mutations in the gyrA and grlA (parC) genes[1]. Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of >10−10 and 5.3 × 10−10, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin[2]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : 6 mg/mL (16.51 mM; Need ultrasonic and warming) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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