BM212 exerts bactericidal activity against intracellular bacilli residing, completely inhibits the intracellular mycobacteria. In vitro: BM212 is inhibitory to drug-resistant mycobacteria and also exerted bactericidal activity against intracellular bacilli residing in the U937 human histiocytic lymphoma cell line.[1] BM212 completely inhibits the intracellular mycobacteria. BM212 had inhibitory activity against all strains tested, with MICs between 0.7 and 1.5 μg/ml.[2]

• [1]. Poce G et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2)

  [2]. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains. Antimicrob Agents Chemother. 1998 Nov;42(11):3035-7.

  [3]. Deidda D et al. Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.