Tebipenem 是一种可口服的广谱的碳青霉烯类抗生素,能够抑制革兰氏阳性菌和革兰氏阴性菌,但对绿脓杆菌无作用。
Description | Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa. | ||||||||||||||||
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In Vitro | Tebipenem exhibits slow tight-binding inhibition at low micromolar concentrations versus the chromogenic substrate nitrocefin, and apparent Km and kcat values of 0.8 μM and 0.03 min-1, respectively[1]. Tebipenem shows potent activity against B. pseudomallei, with MIC50 and MIC90 values of both 2 mg/L[2]. Tebipenem shows good activity against S. pneumoniae, with the MIC range of ≤0.25 μg/mL in all of the S. pneumoniae isolates[3]. | ||||||||||||||||
Solvent & Solubility | In Vitro: DMSO : ≥ 45 mg/mL (117.34 mM) H2O : 6.2 mg/mL (16.17 mM; Need ultrasonic and warming) * "≥" means soluble, but saturation unknown. Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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