Ciprofloxacin hydrochloride 是一种氟喹诺酮类抗生素,具有高效的抗菌活性。
Description | Ciprofloxacin hydrochloride is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. | ||||||||||||||||
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IC50 & Target | Bacterial[1] | ||||||||||||||||
In Vitro | |||||||||||||||||
In Vivo | Ciprofloxacin hydrochloride (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin hydrochloride (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[1]. In a murine model of pneumonic plague, Ciprofloxacin hydrochloride (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin hydrochloride. Intraperitoneal Ciprofloxacin hydrochloride reduces the lung bacterial load compare to controls treated with intraperitoneal PBS[3]. | ||||||||||||||||
Solvent & Solubility | In Vitro: H2O : 12.5 mg/mL (33.99 mM; Need ultrasonic and warming) Preparing Stock Solutions
* Please refer to the solubility information to select the appropriate solvent. | ||||||||||||||||
References | |
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