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Qiagen 凯杰 Biosharp Omega

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Recombinant Human PCSK9/Proprotein Convertase 9 (biotinylated) 1mg

价:
24640.00
价:
¥19712.00

号:P00124-1mg

牌:Solarbio索莱宝

账期 货到付款

EA (预计5-10工作日到货)

工作时间

周一至周五:9:00-18:00

咨询电话

0771-3293894

在线咨询

客服 郭恒 蔡玉坤 曾宪飞 技术咨询

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Known as Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1
Derived from Human cells
Purity Greater than 95% as determined by reducing SDS-PAGE.
Formulation Supplied as a 0.2 μm filtered solution of 50mM HEPES,150mM NaCl,20%Glycerol,pH 7.4.
Shipping The product is shipped on dry ice/ice packs.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
Endotoxin Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Background Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is produced by our Mammalian expression system and the target gene encoding Gln31-Gln152&Ser153-Gln692 is expressed with a AVI tag at the C-terminus.

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