描述
Gibco® Dynamis™ liquid medium is specifically designed to offer the highest batch and fed-batch culture performance and yield with recombinant CHO cells in a chemically defined environment. The chemically defined, protein-free, animal origin component-free formulation provides the power to achieve high titers, start process development faster and streamline or simplify transfer to manufacturing scale.
Power to achieve higher titers Dynamis™ AGT™ Medium is fortified to help maximize recombinant CHO cell growth and protein expression in suspension batch culture, offering 170% greater production than select competitive media with simple glucose supplementation by day 14. Cultures grown in Dynamis™ AGT™ Medium extend to even higher titers demonstrating good cell viability out to day 21. This medium can also provide up to 60% greater fed-batch growth and production over glucose-only fed-batch culture for selected cell lines and applications when used with
EfficientFeed™ C+ AGT™ Supplement.
Power to start process development faster As a fortified medium, Dynamis™ AGT™ provides the power to get to a high cell density over 10 million cells per mL faster than competitive products and sustains that cell density longer by just maintaining glucose levels. The viable cell growth achieved make it a good choice for scale-up if you have started with CD FortiCHO™ medium. When paired with
EfficientFeed™ C+ AGT™ Supplement, it provides a fast and efficient way to develop a process.
The power to streamline transfer to manufacturing Dynamis™ liquid medium is made by reconstitution of Dynamis™ AGT™ dry format into the liquid format. Therefore, you simplify scale-up and manufacturing in AGT™ dry format because you know the liquid will behave exactly like the AGT™ format. The AGT™ dry format scale-up provides easy to reconstitute (just add water) use including auto-pH and auto-osmolarity. This can help provide efficiencies in supply chain complexity, reconstitution complexity and therefore overall expense.
When to Use Dynamis™ Medium • The cell line you are using is a transfected CHO K1, GS CHO or CHO-S™ cell line
• Maximum batch culture cell densities and protein titers are needed
• You have time to adapt cells into a new medium in an effort to maximize titers
• Cell health at harvest is a priority for downstream processing
When to Consider Another Gibco® Medium Consider
CD OptiCHO™ Medium when:
• You are using a transfected CHO cell line other than CHO K1, GS CHO or CHO-S™ cell lines
• Optimization of feeding strategies will be part of your base medium selection testing in an effort to maximize productivity
• Your CHO cell line is “finicky," i.e. hard to grow or adapt
Consider
CD CHO Medium when:
• Your GS CHO cells are recommended to be grown in CD CHO medium
• Your cells have been successfully cultured in CD CHO medium in the past and your process is nearing a regulatory filing (DMF available)
Consider
CD DG44 Medium when:
• You use parental DG44 or DXB11 CHO cells (dhfr-)
Design Your Own Media Specific to Your Needs Whether it’s a bench-level experiment or large scale biomanufacturing process, we offer specialized formats, packaging, and quality levels specific to your needs. With
Gibco® cGMP Media Custom Services you can put the manufacturing power and years of technical experience of our R&D and Bioproduction Application Specialists to work for you.
Gibco® is a registered trademark of ThermoFisher Scientific Inc. Dynamis™ and CD FortiCHO™ are trademarks of Thermo Fisher Scientific Inc., ActiCHO(TM) is a trademark of GE Healthcare Biosciences AB, BalanCD(R) is a registered trademark of Irvine Scientific Sales Co., Cellvento(R) is a registered trademark of Merck KGAA, EXCELL(R) is a registered trademark of SAFC, HyCell(R) is a registered trademark of GE Healthcare Biosciences AB, and PowerCHO(TM) is a registered trademark of Lonza. 
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