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化学信息：
| 化学名 | (2S,3R,4R,5S,6R)-2-[3-(1-benzothiophen-2-ylmethyl)-4-fluorophenyl]-6-(hydroxymethyl)oxane-3,4,5-triol |  |
| 简称 | Ipragliflozin | |
| 别名 | ASP1941, ASP 1941, ASP-1941 | |
| 中文名 | N/A | |
| 化学式 | C21H21FO5S | |
| 分子量 | 404.45 | |
| CAS号 | 761423-87-4 | |
| 纯度 | 98% | |
| 溶剂/溶解度 | Water<1mg/ml; DMSO5mg/ml; Ethanol<1mg/ml | |
| 溶液配制 | 5mg加入1.24ml DMSO，或者每4.04mg加入1ml DMSO，配制成10mM溶液。SF9015-10mM用DMSO配制。 |
生物信息：
| 产品描述 | Ipragliflozin (ASP1941) is a highly potent and selective SGLT2 inhibitor with IC50 of 2.8nM; little and NO potency for SGLT1/3/4/5/6. | ||||
| 信号通路 | Transmembrane Transporters | ||||
| 靶点 | SGLT2 | － | － | － | － |
| IC50 | 2.8nM | － | － | － | － |
| 体外研究 | Ipragliflozin potently and selectively inhibited human, rat, and mouse SGLT2 at nanomolar ranges and exhibited stability against intestinal glucosidases. | ||||
| 体内研究 | Ipragliflozin showed good pharmacokinetic properties following oral dosing, and dose-dependently increased urinary glucose excretion, which lasted for over 12h in normal mice. Oral administration of ipragliflozin increased urinary glucose excretion in a dose-dependent manner, an effect which was significant at doses of 0.3mg/kg or higher and lasted over 12h. Single administration of ipragliflozin dose-dependently increased urinary glucose excretion, reduced blood glucose and plasma insulin levels, and improved glucose intolerance. | ||||
| 临床实验 | N/A | ||||
| 特征 | N/A | ||||
相关实验数据(此数据来自于公开文献，碧云天并不保证其有效性)：
| 酶活性检测实验 | |
| 方法 | N/A |
| 细胞实验 | |
| 细胞系 | N/A |
| 浓度 | N/A |
| 处理时间 | N/A |
| 方法 | N/A |
| 动物实验 | |
| 动物模型 | N/A |
| 配制 | N/A |
| 剂量 | N/A |
| 给药方式 | N/A |
| 产品编号 | 产品名称 | 包装 |
| SF9015-10mM | Ipragliflozin (SGLT2抑制剂) | 10mM×0.2ml |
| SF9015-5mg | Ipragliflozin (SGLT2抑制剂) | 5mg |
| SF9015-25mg | Ipragliflozin (SGLT2抑制剂) | 25mg |
| — | 说明书 | 1份 |
保存条件：
-20℃保存，至少一年有效。5mg和25mg包装也可室温保存，至少6个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
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