Anti-IFN-omega Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-IFN-omega Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IFN-omega
Immunogen
Recombinant Human IFN omega / IFNW1 Protein (Catalog#10353-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFN omega / IFNW1 (rh IFN omega / IFNW1; Catalog#10353-H08H; P05000; Met1-Ser195). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #04
Formulation
0.2 μm filtered solution in PBS
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IFN-omega Antibody (Mouse Monoclonal antibody) Validated Applications
Application | Dilution | Notes |
ELISA | 1:1000-1:2000 | |
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-IFN-omega Antibody Alternative Names
Anti-IFN-omega 1 Antibody;Anti-IFNW1 Antibody;Anti-interferon omega-1 Antibody
IFN-omega Background Information
IFNs are a large family of proteins having antiviral, antiproliferative, and immunomodulatory effects, and are divided into two major classes, type I and type I I, on the basis of differences in receptor binding and nucleotide sequence. Type I IFNs consist of IFN α, β, τ, and ω and bind to the type I IFN receptor, whereas IFN-γ is the only type I I IFN and is specific for the type I I IFN receptor. Human IFN-ω, was identified by three independent groups in 1985 and is structurally related to IFN-α and -β. Both human IFN-ω and IFN-α are produced by virally induced leukocytes and have similar antiviral activities on human cell lines, and a sizeable proportion (at least 1%) of the total antiviral activity of leukocyte IFN is contributed by IFN-ωl. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.
Full Name
interferon, omega 1
References
Capon D.J., et al.,(1985), Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides. Mol. Cell. Biol. 5:768-779. Adolf G.R., et al., (1991), Human interferon omega 1: isolation of the gene, expression in Chinese hamster ovary cells and characterization of the recombinant protein.Biochim. Biophys. Acta 1089:167-174. Humphray S.J., et al.,(2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.