RTN4 qPCR Primer Pairs, Human 基本信息
Target Details
Product Details
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
应用:
SYBR® Green-based quantitative real-time PCR (qPCR).
质控:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
储存 & 运输
运输:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
储存:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.
***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***
Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
RTN4 qPCR Primer Pairs, Human Alternative Names
ASY qPCR Primer Pairs, Human;DGU qPCR Primer Pairs, Human;DKFZp781L1143 qPCR Primer Pairs, Human;HIGM4 qPCR Primer Pairs, Human;Nbla00271 qPCR Primer Pairs, Human;Nbla10545 qPCR Primer Pairs, Human;NI220/250 qPCR Primer Pairs, Human;NOGO qPCR Primer Pairs, Human;NOGO-A qPCR Primer Pairs, Human;Nogo-B qPCR Primer Pairs, Human;Nogo-C qPCR Primer Pairs, Human;NOGOC qPCR Primer Pairs, Human;NSP qPCR Primer Pairs, Human;NSP-CL qPCR Primer Pairs, Human;RTN-X qPCR Primer Pairs, Human;RTN4-A qPCR Primer Pairs, Human;RTN4-B1 qPCR Primer Pairs, Human;RTN4-B2 qPCR Primer Pairs, Human;RTN4-C qPCR Primer Pairs, Human;UDG qPCR Primer Pairs, Human;UNG1 qPCR Primer Pairs, Human;UNG15 qPCR Primer Pairs, Human;UNG2 qPCR Primer Pairs, Human
RTN4 Background Information
Reticulon-4, also known as Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein which contains one reticulon domain. Isoform 1 of RTN4 is specifically expressed in brain and testis and weakly in heart and skeletal muscle. Isoform 2 of RTN4 is widely expressed except for the liver. Isoform 3 of RTN4 is expressed in brain, skeletal muscle and adipocytes. Isoform 4 of RTN4 is testis-specific. Reticulon-4 / RTN4 is a developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon-4 / RTN4 regulates neurite fasciculation, branching and extension in the developing nervous system. Reticulon-4 / RTN4 is involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein processing.
References
Yang J., et al., 2000, Cytogenet. Cell Genet. 88:101-102. Prinjha R., et al., 2000, Nature 403: 383-384. Tagami S., et al., 2000, Oncogene 19: 5736-5746. Murayama K.S., et al., 2006, Eur. J. Neurosci. 24: 1237-1244. Daub H., et al., 2008, Mol. Cell 31:438-448. Choudhary C., et al., 2009, Science 325: 834-840.
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