Preparation and Storage
Background: CRTH-2
CRTH-2 is a 7-transmembrane G-protein coupled receptor that is expressed by activated Th2 cells and eosinophils. CRTH-2 binds prostaglandin D2 and induces chemotaxis of Th2 cells and eosinophils in allergic and inflammatory immune responses. Human and mouse CRTH-2 share 78% amino acid sequence identity.
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Long Name:
Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells
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Entrez Gene IDs:
11251 (Human); 14764 (Mouse); 309212 (Rat)
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Alternate Names:
CD294 antigen; CD294; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH2; CRTH-2; CRTH2chemoattractant receptor homologous molecule expressed on T helper type 2 cells; DL1R; DP2; G protein-coupled receptor 44; GPR44; PGD2R; PTGDR2; putative G-protein coupled receptor 44
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