BDKR2B, a 7TM receptor for the peptide bradykinin, is predominantly expressed on endothelial cells and smooth muscle cells. It plays a key role in the regulation of blood pressure by promoting vasodilation and vascular permeability. BDKR2B heterodimerization with angiotensin II receptors enhances angiotensin II responsiveness. Polymorphisms of BDKR2B are associated with hypertension, cardiovascular risk, and diabetic nephropathy.