Preparation and Storage
Background: EMP2
Epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate with and modify surface expression of certain integrin isoforms, was identified as a prognostic biomarker in human endometrial cancer. EMP2 is expressed in the majority of ovarian tumors and may be a feasible drug target in vivo. EMP2 in several cell types plays a role in growth control, invasion, metastasis, and protein trafficking. It can associate with integrin alpha v beta 3 and FAK, and promote integrin-mediated FAK-Src activation.
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Long Name:
Epithelial Membrane Protein 2
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Entrez Gene IDs:
2013 (Human); 13731 (Mouse); 360468 (Rat)
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Alternate Names:
EMP2; epithelial membrane protein 2; MGC9056; Protein XMP; XMP; XMPEMP-2