Preparation and Storage
Background: GIPR
GIPR is a G protein-coupled receptor for gastric inhibitory polypeptide (GIP). GIP was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking GIPR exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defects in this gene may contribute to the pathogenesis of diabetes.
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Long Name:
Gastric Inhibitory Polypeptide Receptor
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Entrez Gene IDs:
2696 (Human); 381853 (Mouse); 25024 (Rat)
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Alternate Names:
gastric inhibitory polypeptide receptor; GIPR; GIP-R; Glucose-dependent insulinotropic polypeptide receptor; MGC126722; PGQTL2