Preparation and Storage
Background: MICL/CLEC12A
MICL is a member of the group V subfamily of the C-type lectin-like family of molecules. It is found on the cell surface, contains an ITIM (immunoreceptor tyrosine-based inhibitory motif) in its cytoplasmic domain, and is N-glycosylated. Expression of MICL is restricted to granulocytes and monocytes, and it may function as a negative regulator of these cell types. At least three isoforms of MICL are generated by alternative splicing, including one that lacks the transmembrane domain.
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Long Name:
Myeloid Inhibitory C-type Lectin-like Receptor
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Entrez Gene IDs:
160364 (Human); 232413 (Mouse)
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Alternate Names:
CD371; CLEC12A; CLL1; CLL-1; C-type lectin domain family 12, member A; DCAL-2; MICL