The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin, an essential hormone secreted by adipocytes that acts as an antidiabetic. They mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ADIPOR2 is probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation.