EDA2R, also known as TNFRSF27 or XEDAR (X-linked ectodysplasin receptor), is an X-linked member of the TNF receptor superfamily (TNFRSF). Within the TNFRSF, EDA2R shares the highest homologies with EDAR and TNFRSF19/TROY. EDA-A2 is the EDA2R ligand. EDA2R expression is principally found in embryonic hair follicles. EDA2R, EDAR, EDA-A1, and EDA-A2 have been associated with hypohidrotic ectodermal dysplasia (HED).