Preparation and Storage
Background: OX40/TNFRSF4
OX40 (CD134; TNFRSF4) is a T cell costimulatory molecule of the TNF receptor superfamily that coordinates with other costimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is upregulated on antigen activated CD4+ and CD8+ T cells with costimulation by CD40-CD40 Ligand and CD28-B7. OX40 interactions with OX40 Ligand on antigen presenting cells enhances T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs where it promotes Treg proliferation and immunosuppressive activity. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease, and autoimmune disease.
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Entrez Gene IDs:
7293 (Human); 22163 (Mouse); 25572 (Rat); 102145978 (Cynomolgus Monkey)
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Alternate Names:
ACT-135; ACT35 antigen; ACT35ATC35 antigen; CD134 antigen; CD134; Ly-70; OX40 cell surface antigen; OX40 homologue; OX40; OX40L receptor; OX40lymphoid activation antigene ACT35; TAX transcriptionally-activated glycoprotein 1 receptor; tax-transcriptionally activated glycoprotein 1 receptor; TNFRSF4; tumor necrosis factor receptor superfamily member 4; tumor necrosis factor receptor superfamily, member 4; Txgp1; TXGP1L; TXGP1LOX40 antigen