Preparation and Storage
Background: SLAM/CD150
The Signaling Lymphocytic Activation Molecule (SLAM) family of receptor molecules is a subset of the CD2 family of receptors. SLAM proteins function as co-receptors for lymphocyte activation and/or adhesion and mediate tyrosine phosphorylation signals. SLAM receptor expression is mainly restricted to immune cells. SLAM, also known as CD150, is a transmembrane glycoprotein that is upregulated on activated B cells and T cells but downregulated on Th2 polarized cells. SLAM ligation promotes the activation of Th0/Th1 cells, B cells, eosinophils, mast cell, and macrophages. SLAM also functions as a cellular entry receptor for measles virus.
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Long Name:
Signaling Lymphocytic Activation Molecule
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Entrez Gene IDs:
6504 (Human); 27218 (Mouse)
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Alternate Names:
CD 150; CD150; CD150IPO-3; CDw150; IPO-3; signaling lymphocytic activation molecule family member 1; signaling lymphocytic activation molecule; SLAM; SLAMCD150 antigen; SLAMF1