溶解性 | 熔于乙醇、甲醇、丙酮、氯仿、乙腈和乙酸乙酯,中等程度溶于醚、二氯甲烷和乙酸戊酯。难溶于水。微有引湿性,无臭,味苦。遇酸不稳定。水中溶解度:+/- 3 MG/ML。 |
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熔点 | 138-140°C |
密度 | 1.2000 |
旋光率 | -74 ° (C=2, EtOH) |
产品介绍 | Erythromycin is a potent macrolide inhibitor of CYP3A4 with antiinflammatory and prokinetic properties. Macrolides belong to a group of antibiotics that bind to the 50S ribosomal subunit and inhibit protein synthesis. Erythromycin is derived from Streptomyces erythreus and has been shown to inhibit NF-κB transcriptional activation, which leads to the inhibition of cytokine gene expression of IL-8 and lL-6. This mechanism was shown to occur via calcineruin-independent signaling T lymphocytes. |
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用途 | A macrolide antibiotic protein synthesis inhibitor. Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains. |
生化机理 | 在转肽步骤抑制延长期,靠结合到核糖体上抑制细菌蛋白合成,对细菌诱发红霉素抗性。抗菌谱: 革兰氏阴性和阳性细菌。 属大环内酯抗生素(Macrolide antibiotic) |
包装 | E105345-5g,E105345-25g,E105345-100g in poly bottle |
备注 | 此产品所配溶液37°C只能保存3天,因此其储存溶液必须2-8°C保存. This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light. |
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