盐酸阿霉素 Doxorubicin hydrochloride 98% 1g

溶解性	溶于水、DMSO、四氢呋喃和醇，不溶于丙酮、苯、氯仿、乙醚。水中溶解度: 10 mg/mL, 水溶液为橙红色透明溶液。,
敏感性	对光和湿度敏感
存贮条件	储存温度：2-8°C
熔点	216°C
密度	否
荧光	否
IC50	否
pK Values	否

溶解性

溶于水、DMSO、四氢呋喃和醇，不溶于丙酮、苯、氯仿、乙醚。水中溶解度: 10 mg/mL, 水溶液为橙红色透明溶液。,

敏感性

对光和湿度敏感

存贮条件

储存温度：2-8°C

熔点

216°C

产品介绍	Doxorubicin (Adriamycin)是一种抗生素类试剂，抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。
用途	抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。
生化机理	Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.
包装	D107159-1g,D107159-25mg,D107159-100mg,D107159-500mg in glass bottle
合法信息	Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

产品介绍

Doxorubicin (Adriamycin)是一种抗生素类试剂，抑制DNA拓扑异构酶II，且诱导DNA损伤和凋亡。

用途

抗肿瘤抗生素，在心脏线粒体DNA方面有阿霉素的效果。反相转录酶和RNA聚合酶的抑制剂，免疫抑制剂；可插入DNA链中。临床上是癌症化疗剂、主要用于急、慢性白血病、恶性淋巴瘤。

生化机理

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.

包装

D107159-1g,D107159-25mg,D107159-100mg,D107159-500mg in glass bottle

合法信息

Adriamycin is a registered trademark of RDF Pharmacia & Upjohn S.P.A.

实验耗材

分子生物学试剂

蛋白与免疫学

生化试剂

细胞及检测试剂

色谱及层析

仪器设备

实验服务

办公用品

盐酸阿霉素 Doxorubicin hydrochloride 98% 1g

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