溶解性 | Soluble in water (≥113), methanol, ethanol (≥10), and DMSO (≥72 mg/mL). |
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敏感性 | 对湿度敏感 |
存贮条件 | 储存温度2-8°C |
产品介绍 | Daunorubicin HCl抑制DNA和RNA合成,抑制DNA合成时,Ki为0.02 μM。强效抗癌剂,已证明是 DNA 和 RNA 合成的强抑制剂。自发荧光的蒽环类抗生素,抗癌药。Pgp、MRP-1 和 BCRP 的底物。已利用荧光特性来测量药物外排泵活性,以及解?决许多重要问题,如多种多药耐药蛋白的胞内定位和亚细?胞器(高尔基体和溶酶体)在药物螯合中的作用及其在耐?药表型中的含义。根据 pH 分配型机理将柔红霉素螯合进溶酶体。DNA 和 RNA 合成的强抑制剂。 |
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用途 | A DNA intercalator which may suppress acute leukemia proliferation |
生化机理 | Daunorubicin hydrochloride is a DNA intercalating anthracylcine natural product isolated from Streptomyces peucetius. Upon intercalation, Daunorubicin forms stable complexes with the DNA backbone, inhibiting normal functioning of the double helix and the proteins that interact with it. Daunorubicin is nearly identical in structure to Doxorubicin , with Doxorubicin containing a pendant hydroxyl group on the exocyclic ketone. The action of Daunorubicin has been correlated to efficacy in suppressing the proliferation of certain acute leukemias. Daunorubicin hydrochloride is an inhibitor of Topo I and Topo II and an activator of LASS. |
包装 | D122335-10mg,D122335-50mg,D122335-250mg in glass bottle |
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