别名:3-氨基-6-(4-((4-甲基-1-哌嗪基)磺酰基)苯基)-N-3-吡啶基-吡嗪甲酰胺;;AZD 2858;AZD-2858；3-amino-6-(4-((4-methyl-1-piperazinyl)sulfonyl)phenyl)-n-3-pyridinyl-pyrazinecarboxamide

溶解性	25°C: DMSO 7 mg/mL; Water <1 mg/mL; Ethanol <1mg/mL
存贮条件	储存温度-20°C
密度	否
荧光	否
IC50	否
pK Values	否

产品介绍

AZD2858是GSK-3抑制剂，能激活Wnt信号通路。

生化机理

AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway. AZD2858 treatment (1 μM, 12 h) on primary isolated human osteoblast-like cells results in a 3-fold increase of β-catenin levels. AZD2858 causes β-catenin stabilisation in human and rat mesenchymal stem cells, stimulates hADSC commitment towards osteoblasts and osteogenic mineralisation in vitro