See All Kinase Enzyme Systems
Recombinant human TGFβR1 (ALK5) (80–end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. TGFβR1 transforming growth factor beta-receptor 1 is a member of the TGFβ receptor subfamily is a ser/thr protein kinase that forms a heteromeric complex with type II TGFβ receptors when bound to TGFβ, transducing the TGFβ signal from the cell surface to the cytoplasm. Mutations in the TGFβR1 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome the development of various types of tumors (1). TGFβR1-dependent signaling is required for angiogenesis but not for the development of hematopoietic progenitor cells functional hematopoiesis (2).
ADP-Glo™ Kinase Assay is a luminescent kinase assay that measures ADP formed from a kinase reaction; ADP is converted ATP, which is a substrate in a reaction catalyzed by Ultra-Glo™ Luciferase that produces light. The luminescent signal positively correlates with ADP amount kinase activity. The assay is well suited for measuring the effects chemical compounds have on the activity of a broad range of purified kinases, making it ideal for both primary screening as well as kinase selectivity profiling. The ADP-Glo™ Kinase Assay can be used to monitor the activity of virtually any ADP-generating enzyme (e.g., kinase ATPase) using up to 1mM ATP.
Kinase Enzyme System contains:
Human Kinase Enzyme Systems Applications.
Kinase Enzyme System manufactured by SignalChem.
Bulk quantities available upon request.
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