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N-Ac-Asp-Glu-Val-Asp-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively). Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms,are irreversible.Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.
| 产品组份: | Ac-DEVD-CHO：100μl（10mM in DMSO） |
|---|---|
| 应用实验类型: | 辅助试剂 |
| 检测方法: | - |
| 特殊物理化学性质说明: | 结构：N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide化学式： C20H30N4O11分子量：502.5纯度：≥98% by HPLC |
| 试剂盒保存温度: | -20℃，保存12个月 |
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