A recurrence of the malignancy resulted in a wide-spread metastasis from the colon to an abdominal mass.The established cell line consists mainly of individual small spherical and bipolar cells lacking microvilli.The cells synthesize only small quantities of carcinoembryonic antigen (CEA), and are highly tumorigenic in nude mice.The cells are negative for expression of CSAp (CSAp-) and colon antigen 3, negative.The cells are positive for keratin by immunoperoxidase staining.The line was derived from a metastasis of the same tumor from which the SW480 was derived.There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution.The line is positive for expression of c-myc, K-ras, H-ras, N-ras, Myb, sis and fos oncogenes.N-myc oncogene expression was not detected.
种属来源: | 人 |
---|---|
组织来源: | 结肠癌;来自转移部位:淋巴结 |
疾病类型: | Dukes' type C 结直肠腺癌 |
细胞贴壁类型: | 贴壁 |
细胞形态: | 上皮细胞 |
细胞数: | 30-50代 |
培养基: | L-15 |
血清: | FBS |
消化液: | KGY0012 |
成瘤性: | YES |
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