The cells exhibit ion transport activities consistent with cystic fibrosis and express the product of the CF gene (cystic fibrosis transmembrane regulator, CFTR).CFPAC-1 cells show no effect of cAMP agonists, adenyl cyclase stimulators or phosphodiesterase inhibitors on Cl- flux, but do respond to Ca++ ionophores with increase Cl- efflux.The cells have the most common form of the CF mutation, deletion of three nucleotides resulting in the absence of phenylalanine at position 508.CFPAC-1 cells have epithelial morphology and polarization with apical microvilli, tight junctions and gap junctions.
种属来源: | 人 |
---|---|
组织来源: | 胰腺 |
疾病类型: | 胰腺癌 |
细胞贴壁类型: | 贴壁 |
细胞形态: | 上皮样 |
细胞数: | 30-50代 |
培养基: | IMDM(高糖) |
血清: | FBS |
消化液: | KGY0012 |
成瘤性: | YES |
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